Publications by authors named "J A Patino-Galindo"
Article Synopsis
- SARS-CoV-2, the virus responsible for COVID-19, has caused millions of deaths, highlighting the need to understand its emergence and how it spills over to humans.
- A study analyzed recombination among coronaviruses, identifying 199 events with a majority occurring within species rather than between them, and found that these genomic changes predominantly affect specific regions of the virus's genome.
- The research concluded that SARS-CoV-2 likely gained its unique features through recombination with related viruses in the same species, emphasizing the importance of understanding these processes to prevent future outbreaks.
Article Synopsis
- The 2023 monkeypox epidemic originated from a specific lineage of the monkeypox virus traced back to Nigeria in 1971, with a subclade IIb showing higher person-to-person transmission rates due to genomic changes.
- Researchers used advanced techniques to analyze the genome of the monkeypox virus from the current epidemic, highlighting significant variations in low-complexity regions (LCRs) that are often overlooked.
- The study found that variations in LCRs may influence the expression and function of key poxvirus genes, suggesting that future genome studies should focus on these regions to better understand differences in the virus's behavior.
Viral respiratory infections are an important public health concern due to their prevalence, transmissibility, and potential to cause serious disease. Disease severity is the product of several factors beyond the presence of the infectious agent, including specific host immune responses, host genetic makeup, and bacterial coinfections. To understand these interactions within natural infections, we designed a longitudinal cohort study actively surveilling respiratory viruses over the course of 19 months (2016 to 2018) in a diverse cohort in New York City.
View Article and Find Full Text PDFPeripheral T cell lymphoma not otherwise specified (PTCL-NOS) comprises heterogeneous lymphoid malignancies characterized by pleomorphic lymphocytes and variable inflammatory cell-rich tumor microenvironment. Genetic drivers in PTCL-NOS include genomic alterations affecting the VAV1 oncogene; however, their specific role and mechanisms in PTCL-NOS remain incompletely understood. Here we show that expression of Vav1-Myo1f, a recurrent PTCL-associated VAV1 fusion, induces oncogenic transformation of CD4 T cells.
View Article and Find Full Text PDFBackground: The emergence of SARS-CoV-2 underscores the need to better understand the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. In the betacoronavirus genus, which also includes SARS-CoV and MERS-CoV, recombination frequently encompasses the receptor binding domain (RBD) of the Spike protein, which is responsible for viral binding to host cell receptors. In this work, we reconstruct the evolutionary events that have accompanied the emergence of SARS-CoV-2, with a special emphasis on the RBD and its adaptation for binding to its receptor, human ACE2.
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