A Brief Introduction to Current Cancer Gene Therapy.

Gene therapy has started in the late 1980s as novel, clinically applicable therapeutic option. It revolutionized the treatment of genetic diseases with the initial intent to repair or replace defective genes. Gene therapy has been adapted for treatment of malignant diseases to improve the outcome of cancer patients.

Dynamic publication media with the COPASI R Connector (CoRC).

In this article we show how dynamic publication media and the COPASI R Connector (CoRC) can be combined in a natural and synergistic way to communicate (biochemical) models. Dynamic publication media are becoming a popular tool for authors to effectively compose and publish their work. They are built from templates and the final documents are created dynamically.

CoRC: the COPASI R Connector.

Motivation: COPASI is a biochemical simulator and model analyzer which has found widespread use in academic research, teaching and beyond. One of COPASI's strengths is its graphical user interface, and this is what most users work with. COPASI also provides a command-line tool.

Long-term apical bone gain after implant placement combined with internal sinus-floor elevation without graft.

Background: To assess changes in apical bone height/bone gain over up to 8 years after implant placement combined with simultaneous internal sinus-floor elevation (ISFE) without use of graft.

Methods: 217 implants were placed in combination with graft-free ISFE and successfully healed in the posterior maxilla of 138 patients. Radiographs after surgery across an evaluation time of up to 8 years were analyzed.