Differences in post-mortem findings after stillbirth in women with and without diabetes.

Aims: The reason for the fivefold increased risk of stillbirth in women with diabetes is not known. Further understanding of the underlying mechanisms may facilitate identification of pregnancies at increased risk. We have compared post-mortem reports in matched pairs of stillbirths in women with and without diabetes.

No correlation between ultrasound placental grading at 31-34 weeks of gestation and a surrogate estimate of organ function at term obtained by stereological analysis.

We test the experimental hypothesis that early changes in the ultrasound appearance of the placenta reflect poor or reduced placental function. The sonographic (Grannum) grade of placental maturity was compared to placental function as expressed by the morphometric oxygen diffusive conductance of the villous membrane. Ultrasonography was used to assess the Grannum grade of 32 placentas at 31-34 weeks of gestation.

Oxygen consumption of cycle ergometry is nonlinearly related to work rate and pedal rate.

The purpose of the study was to develop an equation to predict the oxygen cost of cycle ergometry. Forty subjects performed an incremental cycle ergometer test on three occasions at 50, 70, or 90 rpm in a counterbalanced order. Work rate was incremented every 5 or 6 min when steady rate values were achieved.

Overexpression of p53 in Hodgkin's disease: lack of correlation with Epstein-Barr virus infection.

Recent work has shown that p53 gene mutations are frequently found in Epstein-Barr virus (EBV)-positive and EBV-negative cases of Burkitt's lymphoma but not in EBV-associated undifferentiated nasopharyngeal carcinomas (NPCs). Similar viral gene expression patterns are observed in undifferentiated NPCs and in EBV-positive cases of Hodgkin's disease (HD), suggesting that the contribution of the virus to the pathogenesis of these malignancies may also be similar. We have analysed 116 cases of HD for EBV association and for immunohistologically detectable overexpression of p53.

A comparison of the regional deposition in a model nose of a drug discharged from metered aerosol and metered-pump nasal delivery systems.

The morphology and airflow behavior in the nose are considered briefly in relationship to the various ways that are often used to evaluate the spray or aerosol discharged from inhalation delivery systems. A glass-model nose of a design based on published anatomic measurements is described. Its use is described for examining the major sites of drug deposition from nasal delivery systems.