The next 5 years at the Interface of Exercise and the Airway.

Exercise is strongly recommended in almost all populations for its beneficial effects on physical and mental health. This edition of Clinics features state-of-the-art reviews of the most commonly encountered respiratory causes of shortness of breath during exercise in active individuals, including nasal obstructions, exercise-induced laryngeal obstruction, excessive dynamic airways collapse, exercise-induced bronchoconstriction with and without asthma, and breathing-pattern disorder. The goals of this edition include summarizing knowledge of these conditions, creating a new wave of experts in the field, and inspiring readers to contribute to the field from around the globe.

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS).

Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS have not been evaluated for developmental toxicity potential. A concentration-response study of 182 unique PFAS chemicals using the zebrafish medium-throughput, developmental vertebrate toxicity assay was conducted to investigate chemical structural identifiers for toxicity.