Publications by authors named "J A Nolta"
Background Aims: Despite promising results in pre-clinical studies, mesenchymal stromal cells (MSCs) face significant challenges in clinical translation. A scoping review by our group highlighted two key issues contributing to this gap: (i) lack of a clear and consensus definition for MSCs and (ii) under-reporting of critical parameters in MSC clinical studies. To address these issues, we conducted a modified Delphi study to establish and implement a consensus definition for MSCs and develop reporting guidelines for MSC clinical studies.
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- * The study found that iPSC-derived midbrain neurons from patients with Jordan syndrome exhibited notable differences in dopamine-related pathways and neuronal structure.
- * Researchers tested a CRISPR-based method to correct genetic mutations in neural stem cells, discovering that factors like sgRNA length and cell type affect the efficiency of RNA editing, suggesting a promising avenue for treating NDDs.
Article Synopsis
- The study aimed to assess the feasibility and safety of injecting CD34+ stem cells harvested from bone marrow into the eyes of seven patients with vision loss caused by retinitis pigmentosa (RP).
- Researchers conducted a Phase I, open-label trial, where comprehensive eye examinations were performed at multiple time points, and bone marrow was collected for stem cell isolation and injection on the same day.
- Results showed that all CD34+ cells used were viable and safe, with most participants maintaining or improving their visual acuity and field during the 6-month follow-up, despite one case of a minor transient adverse effect.
Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc (SAMP), a chronic and spontaneous murine model of small intestinal inflammation, to study the therapeutic effects and mechanism of action of human bone marrow-derived MSCs (hMSC).
View Article and Find Full Text PDFHuman embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) hold great potential in regenerative medicine. These cells can be expanded indefinitely in theory and are able to differentiate into different types of cells for cell therapies, drug screening, and basic biology studies. The reliable and effective propagation of hESCs and hiPSCs is important for their downstream applications.
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