Rates of Population-Level Child Sexual Abuse After a Community-Wide Preventive Intervention.

Importance: Child sexual abuse (CSA) impacts 15% of girls and 8% of boys worldwide, incurring high public costs and devastating consequences for survivors. US incidence rates have stagnated over the past 15 to 20 years, signaling a dire need for innovation in primary prevention. In 2024, the US Preventive Services Task Force reported that there is insufficient evidence for the effectiveness of child abuse preventive strategies, and none have shown decreases in incidence rates at the population level.

Parenchymal and inflammatory responses to ozone exposure in the aging healthy and surfactant protein C mutant lung.

Ozone (O) is a ubiquitous pollutant known to produce acute, transient inflammation through oxidative injury and inflammation. These effects are exacerbated in susceptible populations, such as the elderly and those exhibiting genetic mutations in central nodes of pulmonary function. To comprehend the impact of these predisposing factors, the present study examines structural, mechanical, and immunological responses to single acute O exposure (0.

Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research.

Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 typically developing children 2-months to 20-years-old.

Cross-tissue comparison of epigenetic aging clocks in humans.

Epigenetic clocks are a common group of tools used to measure biological aging-the progressive deterioration of cells, tissues, and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues, but there is growing interest in estimating epigenetic age using less-invasive oral-based tissues (i.e.

Prevalence and characteristics of online child sexual victimization: Findings from the Australian Child Maltreatment Study.

Background: Online child sexual victimization is increasingly facilitated by technology, but evidence of its prevalence and characteristics remains scarce. Reliable population-based data is critical to understand the magnitude and nature of the problem, and inform evidence-based prevention.

Objective: To determine the prevalence of nonconsensual sharing of sexual images of the child by any perpetrator, and of online sexual solicitation by any adult perpetrator; and to determine the characteristics of these experiences.