Reasons for donor heart offer refusal are often unrelated to the donor itself - when, why, and the "weekend effect".

Background: Most donor hearts offered for heart transplant (HT) in the United States (US) are turned down. We aimed to understand the reasons for this - focusing on those related to the potential recipient and HT center (i.e.

Tracing acid mine drainage from an accidental spill on the Estuary of Huelva (SW Spain).

The Estuary of Huelva in southwestern Spain is severely impacted by acid mine drainage (AMD), primarily due to extensive mining activities in the Iberian Pyrite Belt (IPB), and to a lesser extent by industrial sources. The AMD has led to significant contamination of the Odiel and Tinto rivers, which carry high loads of metals into the estuary. In May 2017, an accidental spill occurred at La Zarza mine, releasing approximately 270,000 m of acidic water contained in a pit lake.

Harnessing STING Signaling and Natural Killer Cells overcomes PARP Inhibitor Resistance in Homologous Recombination Deficient Breast Cancer.

Homologous recombination deficiency (HRD) contributes to genomic instability and leads to sensitivity to poly ADP-ribose polymerase inhibitors (PARPi). HRD also activates the cyclic GMP-AMP synthase (cGAS)-STimulator of INterferon Genes (STING)-Interferon (IFN) pathway, highlighting the need to understand the impact of cGAS-STING-IFN signaling on PARPi efficacy. In this study, we analyzed a cohort of thirty-five breast cancer (BC) patient-derived xenografts (PDX) and mouse-derived allografts (MDA).

Different methods of perfusate administration do not have an effect on synovial concentrations of amikacin following intravenous regional limb perfusion.

Objective: To determine if different methods of perfusate instillation influence synovial amikacin concentrations in the radiocarpal joint (RCJ) after IV regional limb perfusion (IVRLP).

Methods: 6 healthy horses received an IVRLP using 2 different methods: (1) 2 g amikacin followed by 52 mL 0.9% NaCl (60 mL total; perfusate-A) and (2) 2 g amikacin diluted to 60 mL with 0.

What to Look for in Chest X-Rays of Pediatric Patients With COVID-19: Insights From a Colombian Cohort.

Background: Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are crucial to the initial treatment of patients. This study aims to characterize the radiological findings in pediatric patients with confirmed SARS-CoV-2 infection in Colombia between April 2020 and November 2021, as well as describe the clinical presentation, including those admission to intensive care.