Publications by authors named "J A N Dorresteijn"
Electrochemical reduction of carbon dioxide (CO) into sustainable fuels and base chemicals requires precise control over and understanding of activity, selectivity and stability descriptors of the electrocatalyst under operation. Identification of the active phase under working conditions, but also deactivation factors after prolonged operation, are of the utmost importance to further improve electrocatalysts for electrochemical CO conversion. Here, we present a multiscale in situ investigation of activation and deactivation pathways of oxide-derived copper electrocatalysts under CO reduction conditions.
View Article and Find Full Text PDFPolyolefins are the main building blocks for consumer products. Here, chitosan, a biopolymer that can be derived from abundant fishery waste, is shaped as a microspheroidal support using spray drying to facilitate ethylene polymerization. Definitive screening design was used to optimize synthesis steps efficiently.
View Article and Find Full Text PDFImportance: Elevated lipoprotein(a) increases the risk of atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis.
Objective: To evaluate the effects of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), on lipoprotein(a) serum concentration.
Design, Setting, And Participants: A multicenter trial in patients with stable ASCVD with serum lipoprotein(a) concentrations greater than or equal to 125 nmol/L at 26 sites in Europe and South Africa between January 3, 2023, and April 27, 2023, with last follow-up on July 1, 2024.
Article Synopsis
- After 3 months of anticoagulation treatment for venous thromboembolism (VTE), clinicians must decide on continuing or stopping the treatment, ideally guided by the VTE-PREDICT calculator that estimates risks of recurrence and bleeding.
- A study involved clinicians evaluating fictional VTE cases; some made duration proposals without calculator input (Group A), while others used the calculator to inform their decisions (Group B).
- Results showed no overall difference in proposed durations between the two groups, yet many in Group A adjusted their recommendations after seeing the calculator risks, noting its usefulness, particularly for patients at high bleeding risk.
Background: Current prediction models for mainland Europe do not include ethnicity, despite ethnic disparities in cardiovascular disease (CVD) risk. SCORE2 performance was evaluated across the largest ethnic groups in the Netherlands and ethnic backgrounds were added to the model.
Methods: 11,614 participants, aged between 40 and 70 years without CVD, from the population-based multi-ethnic HELIUS study were included.