Publications by authors named "J A Mulligan"
Rationale: Smoking has been shown to be associated with circulating deficiencies in 25(OH)D3 and reduced sinonasal tissue levels of the active form of vitamin D, 1,25(OH)2D3. Given vitamin D's ability to reduce inflammation, we sought to examine if intranasal (IN) delivery of calcitriol [clinical analog of 1,25(OH)2D3] could reduce inflammation and improve disease severity in a murine model of chronic cigarette smoke-induced sinonasal inflammation (CS-SI).
Methods: Mice were exposed to CS 5 h/day, 5 days/week for 9 months, and then began IN calcitriol three times per week for 4 weeks.
Background: Quantitative mucus cytokine analysis to examine the sinonasal microenvironment may bridge the gap between patient-reported outcome measures (PROMs) and empirical measures of inflammation in patients with chronic rhinosinusitis (CRS).
Objective: Investigate the correlation between mucus cytokine levels and Sino-Nasal Outcome Test (SNOT-22) scores, including individual subdomains.
Methods: Patients with CRS were prospectively recruited between 2016 and 2021 into a multi-institutional observational study.
Individuals in the United States with lower economic resources face a disproportionate burden of obesity and co-morbid conditions. This review summarizes the efficacy of MR programs for the treatment of obesity and diabetes and alerts clinicians to potential barriers and facilitators to the uptake of such programs so they may tailor their prescriptive approach. Implementation of effective behavioral and lifestyle interventions for obesity and diabetes in low-income settings is fraught with barriers and under-studied.
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- The study examines the preoperative olfactory function in patients undergoing endoscopic skull base surgery (ESBS) and functional endoscopic sinus surgery (FESS), highlighting a knowledge gap compared to FESS assessments.
- It analyzed data from 171 patients, revealing that only 57% accurately reported their preoperative olfactory function, with a notable discrepancy between actual hyposmia and patient reports, particularly in those undergoing ESBS.
- The findings point to a significant underreporting of olfactory issues in ESBS patients and discrepancies in the FESS cohort, suggesting a need for more thorough olfactory testing to improve prognostic certainty and address medicolegal concerns.
Article Synopsis
- The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
- It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
- The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.