Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.

Granular cell tumors occur in a variety of sites, including the breast (6%). Origins from histiocytic, myogenic, fibroblastic, and neurogenic elements have been proposed. Female predominance suggests that estrogenic hormones are involved.

Correlation of mean nuclear area with estrogen receptor content in aspiration cytology of breast carcinoma.

Thin needle aspirates of 42 consecutive breast carcinomas were obtained at the time of excisional biopsy. Nuclear diameters of 100 cells from each case were measured, and the nuclear areas were calculated. The concomitantly acquired histologic sections were reviewed and assigned a histologic grade according to the National Surgical Adjuvant Breast Project protocol no.

The correlation of cytologic grade and steroid receptor content in effusions of metastatic breast carcinoma.

The synthesis of estrogen receptor (ER) and progesterone receptor (PR) proteins by mammary carcinoma cells is a manifestation of biochemical differentiation. This study was an attempt to determine whether this acquisition of functional differentiation correlates with cytologic differentiation. Malignant effusions from 30 patients with mammary carcinoma were studied.

Multicentric renal oncocytoma.

Renal cell oncocytomas are benign tumors of tubular epithelial origin. They usually occur as single nodules and may be confused clinically with renal cell carcinoma. We report an unusual case of multiple, discrete renal cell oncocytomas.