Publications by authors named "J A Moreno-Cabezuelo"
Synechococcus sp. PCC 11901 (PCC 11901) is a fast-growing marine cyanobacterial strain that has a capacity for sustained biomass accumulation to very high cell densities, comparable to that achieved by commercially relevant heterotrophic organisms. However, genetic tools to engineer PCC 11901 for biotechnology applications are limited.
View Article and Find Full Text PDFCyanobacteria evolved the oxygenic photosynthesis to generate organic matter from CO and sunlight, and they were responsible for the production of oxygen in the Earth's atmosphere. This made them a model for photosynthetic organisms, since they are easier to study than higher plants. Early studies suggested that only a minority among cyanobacteria might assimilate organic compounds, being considered mostly autotrophic for decades.
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- The study analyzed the effects of glucose (100 nM and 5 mM) on the proteome and metabolome of various marine cyanobacteria strains grown in different light conditions, revealing glucose metabolism through oxidative pentose and Calvin pathways without evidence of the Entner-Doudoroff pathway.
- It found variations in how glucose affected different strains, with some strains showing evidence of fermentation and indicating capabilities for metabolism even in darkness, suggesting a role for glucose in supporting survival.
- The research highlights that marine cyanobacteria are mixotrophic, utilizing both sunlight and organic matter, while also revealing a potential link between glucose assimilation and circadian rhythms through the proteins KaiB and KaiC.
The marine cyanobacterium Prochlorococcus is one of the main primary producers on Earth, which can take up glucose by using the high affinity, multiphasic transporter GlcH. We report here the overexpression of glcH from Prochlorococcus marinus strain SS120 in Escherichia coli. Modeling studies of GlcH using the homologous MelB melibiose transporter from Salmonella enterica serovar Typhimurium showed high conservation at the overall fold.
View Article and Find Full Text PDFsp. PCC 11901 reportedly demonstrates the highest, most sustained growth of any known cyanobacterium under optimized conditions. Due to its recent discovery, our knowledge of its biology, including the factors underlying sustained, fast growth, is limited.
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