Publications by authors named "J A Merriman"
Background: Academic medical centers are experiencing rapid clinical growth which has outpaced traditional teaching services. Learners such as medical students, advanced practice provider fellows, and residents may be placed onto direct care teaching services (i.e.
View Article and Find Full Text PDFObjective: Few studies have examined aromatase inhibitor therapy relating to role function in breast cancer survivors of working age. Our study sought to identify how pre-therapy sociodemographic and health/treatment-related characteristics, as well as patient-reported symptoms measured every six-months, influence role function during 18 months of AI therapy for early-stage breast cancer.
Methods: We performed a secondary analysis of longitudinal study data using linear mixed-effects modeling to examine role physical (RP) and role emotional (RE) functioning measured with the Medical Outcome Study Short Form 36 v2.
Article Synopsis
- - Histoplasma capsulatum is a fungal pathogen found mainly in the Mississippi and Ohio River Valleys, as well as parts of Central and South America, and can reactivate in people with weakened immune systems.
- - A case study describes a 72-year-old man who developed a painful tongue ulcer after starting immunosuppressive treatment for arthritis, revealing a latent infection with H. capsulatum that he likely contracted years earlier during military service in Central America.
- - This case emphasizes the need for healthcare providers to be aware of the risks of histoplasmosis in patients with potential exposure to endemic areas, particularly before starting immunosuppressive therapies.
The skin microbiome plays a pivotal role in the production of attractive cues detected by mosquitoes. Here, we leveraged recent advances in genetic engineering to significantly reduce the production of L-(+)-lactic acid as a strategy to reduce mosquito attraction to the highly prominent skin commensals and Engraftment of these engineered bacteria onto the skin of mice reduced mosquito attraction and feeding for up to 11 uninterrupted days, which is considerably longer than the several hours of protection conferred by the leading chemical repellent N,N-diethyl-meta-toluamide. Taken together, our findings demonstrate engineering the skin microbiome to reduce attractive volatiles represents an innovative untapped strategy to reduce vector attraction, preventing bites, and pathogen transmission.
View Article and Find Full Text PDFBackground: Antidepressants are among the most commonly prescribed medications, but evidence on comparative weight change for specific first-line treatments is limited.
Objective: To compare weight change across common first-line antidepressant treatments by emulating a target trial.
Design: Observational cohort study over 24 months.