Context-Dependent Estrogenic Actions of (+)-Pisatin Produced in Elicited Green or Snow Pea ().

Legumes are a predominant source of isoflavones, termed phytoestrogens, that mimic 17β-estradiol (E2). Phytoalexins are inducible isoflavones produced in plants subjected to environmental stressors (e.g.

Correction: Impact of lanthanide ion complexation and temperature on the chemical reactivity of ,,','-tetraoctyl diglycolamide (TODGA) with the dodecane radical cation.

Correction for 'Impact of lanthanide ion complexation and temperature on the chemical reactivity of ,,','-tetraoctyl diglycolamide (TODGA) with the dodecane radical cation' by Gregory P. Horne , , 2023, , 16404-16413, https://doi.org/10.

A novel outer membrane vesicle adjuvant improves vaccine protection against Bordetella pertussis.

Pertussis is a vaccine-preventable respiratory disease caused by the Gram negative coccobacillus Bordetella pertussis. The licensed acellular pertussis (aP) vaccines protect against disease but do not prevent bacterial colonization and transmission. Here, we developed and tested an intranasal vaccine composed of aP antigens combined with T-vant, a novel adjuvant derived from bacterial outer membrane vesicles, that elicits both mucosal and systemic immune responses.

Real-World Outcomes of Immunotherapy for Melanoma Brain Metastases in New Zealand.

Purpose: Melanoma brain metastases (BMs) are associated with poor survival. Combination immune checkpoint inhibitors (ICIs) with anti-PD1 and anti-CTLA-4 are the international standard-of-care treatment. Most landmark clinical trials excluded real-world patients with symptomatic disease, poor performance status (PS), and steroid use.

Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement.

Background: Sex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in men's health. Lower testosterone level is associated with cardiovascular and cardiometabolic diseases, including inflammation, atherosclerosis, and type 2 diabetes.