Publications by authors named "J A McKEON"
Objectives: Recovery-oriented approaches are gaining increased attention in the mental health sector, including from the World Health Organization and the United Nations, for their potential to support people in recovering and building meaningful lives through strengths-based, person-centered principles. Kyrie Therapeutic Farm (KTF) is a new initiative in Ireland that seeks to develop recovery-oriented model of adult mental health care. The aim of this study was to explore the barriers and facilitators of recovery-oriented models of practice in a small number of therapeutic farm settings across the world in order to inform service design at KTF whilst also addressing a gap in research on this topic.
View Article and Find Full Text PDFPercutaneous Screw Fixation of Proximal Fifth Metatarsal Fractures.
JBJS Essent Surg Tech
November 2024
Article Synopsis
- Metatarsal fractures, particularly affecting the fifth metatarsal, are common injuries, making up 5-6% of outpatient fractures, with zone 2 fractures—specifically Jones fractures—being difficult to manage due to poor blood supply and higher nonunion rates.
- Surgical treatment, particularly open reduction and internal fixation (ORIF), is preferred for Jones fractures, as it leads to better healing rates compared to conservative treatment methods.
- The surgical technique involves careful anatomical marking and using a guidewire for screw placement to compress the fracture, followed by a recovery period that includes non-weight-bearing and gradual weight-bearing activities.*
Primary amoebic meningoencephalitis (PAM) is a human brain infection caused by with a 97% mortality rate. Quinazolinones resulting from a Mannich-coupled domino rearrangement were recently identified as inhibitors of the amoeba. Herein, we resolved the effective concentrations for 25 pilot compounds and then, using the Mannich protocol and a key late-stage, -demethylation/functionalization, we synthesized 53 additional analogs to improve potency, solubility and microsomal stability.
View Article and Find Full Text PDFSemilocal and random phase approximation (RPA) density functional theory (DFT) and complete active space (CASSCF + NEVPT2) methodologies were applied to investigate a new class of extended metal atom chain (EMAC) complexes. A novel triferrous complex has been synthesized recently that does not utilize the usual 2,2'-dipyridylamine (dpa) ligand framework, which essentially always results in a tetragonal coordination environment and general formula M(dpa)X, where X is an anion. Instead, the triferrous complex utilizes a dianionic, 2,6-bis(trimethylsilylamido)pyridine ligand (L) resulting in the formation of trigonal complexes with general formula .
View Article and Find Full Text PDFArticle Synopsis
- * A comprehensive literature search found 25 relevant studies indicating that while cervical collars can improve short-term outcomes and pain control for fusion procedures, they do not significantly affect fusion rates.
- * For motion-preserving surgeries like cervical laminoplasty, extended use of collars may lead to increased neck pain and reduced range of motion, suggesting their benefits diminish over time.