Publications by authors named "J A McGuigan"
Background Chronic lateral ankle instability (CLAI) is caused by lateral ankle ligament weakness or rupture secondary to recurrent sprains. The surgical management has traditionally involved a modified Broström-Gould (MBG) procedure with or without internal brace (IB) augmentation. This study aims to demonstrate the improved outcomes for patients undergoing an MBG procedure with IB augmentation for CLAI.
View Article and Find Full Text PDFUnlabelled: Inflammation skews bone marrow hematopoiesis increasing the production of myeloid effector cells at the expense of steady-state erythropoiesis. A compensatory stress erythropoiesis response is induced to maintain homeostasis until inflammation is resolved. In contrast to steady-state erythroid progenitors, stress erythroid progenitors (SEPs) utilize signals induced by inflammatory stimuli.
View Article and Find Full Text PDFMacrophages play a pivotal role in mediating inflammation and subsequent resolution of inflammation. The availability of selenium as a micronutrient and the subsequent biosynthesis of selenoproteins, containing the 21 amino acid selenocysteine (Sec), are important for the physiological functions of macrophages. Selenoproteins regulate the redox tone in macrophages during inflammation, the early onset of which involves oxidative burst of reactive oxygen and nitrogen species.
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- The genetic encoding of single nucleotide polymorphisms (SNPs) typically relies on traditional models (additive, dominant, recessive), but these may not accurately represent all SNPs, leading to a high multiple testing burden.
- The novel elastic data-driven genetic encoding (EDGE) assigns heterozygous values to SNPs based on the specific model they demonstrate in a given dataset, showing superior power to detect genetic interactions with lower false-positive rates compared to traditional methods.
- In analyses of genetic data from various phenotypes, EDGE successfully identified novel SNP-SNP interactions (e.g., for age-related cataract) that were missed by traditional encodings, suggesting its effectiveness in genetic studies.
Environmental exposure pathophysiology related to smoking can yield metabolic changes that are difficult to describe in a biologically informative fashion with manual proprietary software. Nuclear magnetic resonance (NMR) spectroscopy detects compounds found in biofluids yielding a metabolic snapshot. We applied our semi-automated NMR pipeline for a secondary analysis of a smoking study (MTBLS374 from the MetaboLights repository) (n = 112).
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