Publications by authors named "J A McAuliffe"
Article Synopsis
- Melanoma antigen gene (MAGE)-type antigens are effective targets for cancer immunotherapy, as they appear in cancer cells but not in normal tissues, with the exception of some male germline cells.
- Researchers focused on the mouse P1A antigen, identifying a specific CD8 T-cell epitope presented by the H-2D molecule in C57BL/6 mice, using adenovirus and modified vaccinia Ankara vaccines to enhance immune responses.
- The study successfully induced a strong immune response targeting a specific 9-amino acid peptide from the P1A antigen, leading to protection against specific tumors and the identification of T-cell receptors (TCRs) that could be used for adoptive cell therapy.
Rosai-Dorfman disease (RDD) is a non-Langerhans cell histiocytosis which usually presents as painless lymphadenopathy. Extranodal involvement is known to occur in various organs, and less than ten cases with primary pancreatic involvement have been reported previously. This case report details the clinical course of an elderly female, presenting with upper abdominal discomfort and imaging suggestive of malignancy.
View Article and Find Full Text PDFLife on Earth uses DNA as the central template for self-replication, genetic encoding, and information transfer. However, there are no physical laws precluding life's existence elsewhere in space, and alternative life forms may not need DNA. In the search for exobiology, knowing what to look for as a biosignature remains a challenge - especially if it is not from the obvious list of biologic building blocks.
View Article and Find Full Text PDFCecal volvulus is a rare and life-threatening cause of intestinal obstruction with multiple risk factors including prior abdominal surgery and cecal hypermobility. Although its incidence has been reported after common procedures such as cholecystectomy and appendectomy, it has not been well studied after laparoscopy, especially in gynecological surgeries. If untreated, a cecal volvulus can result in serious complications such as intestinal strangulation, necrosis, or perforation.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated the safety of outpatient total thyroidectomy in 183 patients with hyperthyroidism over a seven-year period, focusing on complications and postoperative outcomes.
- Results showed no instances of thyroid storm, with low rates of complications like vocal nerve damage and hypocalcemia, along with minimal emergency department visits and no readmissions.
- The findings suggest that outpatient surgery could be a viable option for hyperthyroid patients, highlighting the need for further research to understand factors influencing postoperative risks.