Publications by authors named "J A Margenthaler"
Background: Breast conservation therapy for patients with DCIS includes breast conserving surgery (BCS) with post-operative radiotherapy (RT). Because RT does not impact overall survival, identifying women who do not benefit from RT would allow de-escalation of therapy. We evaluated the impact of a novel 7-gene DCIS biosignature on adjuvant radiation recommendations for patients undergoing BCS for DCIS.
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- Breast cancer (BC) has distinct molecular subtypes influenced by different cell origins, yet the transcriptional networks for these subtypes are not well understood.
- This study utilized advanced techniques on 61 samples from 37 BC patients to reveal how gene expression and chromatin accessibility connect BC subtypes to their likely cells of origin.
- Key transcription factors BHLHE40 and KLF5 were found to play crucial roles in luminal and basal-like tumors, respectively, and exhausted CD8 T cells were linked to immune dysfunction in basal-like BC, showcasing the potential of single-cell level analysis in understanding cancer lineages.
Background: Direct-to-implant (DTI) breast reconstruction after mastectomy has gained increasing popularity. While concerns over ischemic complications related to tension on the mastectomy flap persist, newer techniques and technologies have enhanced safety of this technique.
Objectives: To compare clinical and patient-reported outcomes of DTI and 2-stage tissue expander (TE) reconstruction.
Background: Several acellular dermal matrices (ADMs) are used for soft-tissue support in prosthetic breast reconstruction. Little high-level evidence supports the use of one ADM over another. The authors sought to compare Cortiva 1-mm Allograft Dermis with AlloDerm RTU (ready to use), the most studied ADM in the literature.
View Article and Find Full Text PDFBreast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast cancer subtypes have different cells of origin within that lineage. The precise cells of origin for each subtype and the transcriptional networks that characterize these tumor-normal lineages are not established.
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