Publications by authors named "J A Marcondes"
Early and long-term outcome of surgical versus conservative management for intracranial cerebral cavernous malformation: Meta-analysis of reconstructed time-to-event data.
Gustavo da Fontoura Galvão Gabriel Verly Pablo Valença Flávio Sampaio Domingues Marcello Reis da Silva Jorge Marcondes
Clin Neurol Neurosurg
November 2024
Article Synopsis
- The meta-analysis explores the effectiveness of surgical intervention versus conservative management for symptomatic cerebral cavernous malformations (CCMs), tackling the challenges of uncertain clinical management due to limited trial data.
- Results indicate that while surgical intervention might lead to more events (neurological deficits or bleeding) in the long run, observational management showed a longer mean time before these events occurred.
- The study concludes that observational management could offer better long-term outcomes and emphasizes the necessity for more research, including randomized controlled trials, to improve treatment approaches for CCMs.
Article Synopsis
- Cavernomas are genetic vascular lesions located in the central nervous system that may require alternative treatment options, like Gamma Knife stereotactic radiosurgery (GKSRS), when found in critical areas where surgery is not advisable.
- A systematic review and meta-analysis of seven studies involving 1,071 patients revealed that GKSRS had an 89.8% events-free rate at two years and 71.3% at ten years following treatment.
- The findings suggest that GKSRS is a promising alternative for managing symptomatic cavernomas, but further research is necessary to strengthen these conclusions.
Influence of Phenotypes on the Metabolic Syndrome of Women with Polycystic Ovary Syndrome over a Six-Year Follow-Up in Brazil.
Jose Maria Soares-Jr Sylvia Asaka Yamashita Hayashida Jose Antonio Miguel Marcondes Gustavo Arantes Rosa Maciel Cristiano Roberto Grimaldi Barcellos
Biomedicines
December 2023
Background: We followed polycystic ovary syndrome (PCOS) women with metabolic syndrome (MS) over a six-year treatment period and evaluated the influence of PCOS phenotypes on MS and on the risk for type 2 diabetes mellitus (T2DM).
Methods: This was an observational study of 457 PCOS women, whose demographic, clinical, hormonal, and metabolic data underwent analysis. The PCOS women were divided into four groups per NIH recommendations.
Article Synopsis
- Temporal lobe epilepsy linked to hippocampal sclerosis is influenced by complex networks in the brain rather than just a single area of damage.
- A study involving 27 patients and 14 controls used advanced MRI techniques to analyze structural brain networks, finding that patients with fewer seizures had distinct network characteristics compared to those with more frequent seizures and healthy controls.
- While patients didn’t show overall network alterations, those with a lower seizure frequency displayed a more random network organization, while higher seizure rates were associated with a more rigid network structure.