Publications by authors named "J A Mahon"

SPECT/CT combines scintigraphy with a CT scan forming a 3-dimensional reconstruction of bone-tracer uptake patterns. It has become a fundamental component of the work-up of a painful total knee arthroplasty (TKA). The addition of an arthrogram is purported to improve its diagnostic yield.

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There is an urgent need to rapidly reduce greenhouse gas (GHG) emissions and, although human activity is a primary driver of emissions, a knowledge gap remains in terms of the key individual and collective drivers of emissions, and on how to harmonise citizen-led climate action with top-down emissions mitigation policy. In response to this, an urban decarbonisation framework which was informed by systems thinking was developed to support multi-level climate action and decision making. Another aim was to demonstrate the integration of a data-driven and activity-based GHG emissions model for individuals into the framework to enable decarbonisation.

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Increasing uptake and completion of Pulmonary Rehabilitation in people with COPD has the potential to deliver health benefit and reduce health inequalities. We have quantified the cost-effectiveness of enhancing PR access and completion by reviewing the cost-effectiveness literature for PR in COPD. A literature review identified studies that provided cost-effectiveness evidence for PR compared to no PR.

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Article Synopsis
  • Renal cell carcinoma is the most prevalent kidney cancer, representing about 85% of renal cancers, with patients categorized based on their risk for disease progression.
  • The objective of the appraisal was to evaluate the effectiveness and cost-effectiveness of the drug combination lenvatinib plus pembrolizumab compared to other approved treatments such as sunitinib and nivolumab plus ipilimumab.
  • The assessment relied on systematic reviews and meta-analyses, specifically analyzing data from the CLEAR trial, which supported the efficacy and safety of lenvatinib combined with pembrolizumab over sunitinib.
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