Publications by authors named "J A Magnuson"
The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g.
View Article and Find Full Text PDFIn recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in the widespread environmental detection of perfluorohexanesulfonic acid (PFHxS), a short-chain PFAS. However, there remains limited information about the potential adverse effects of PFHxS at environmental concentrations to wildlife. Here, early life stage zebrafish () were exposed to environmentally relevant concentrations of PFHxS to better characterize the adverse effects of PFHxS on aquatic organisms.
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- Bisphenol A (BPA) is a common industrial chemical found in plastics, known for its toxic effects on aquatic life, including cytotoxicity and endocrine disruption.
- The study developed a new in vitro cell culture system from Daphnia magna embryos to conduct toxicity testing more ethically and efficiently, demonstrating that the cultures could be maintained for two months.
- Results showed that BPA exposure significantly increased antioxidant activity and gene expression related to stress responses while causing notable DNA damage, establishing the in vitro Daphnia model as a viable alternative to traditional methods in ecotoxicological research.
There is disagreement among cognitive scientists as to whether a key computational framework - the Simple Recurrent Network (SRN; Elman, Machine Learning, 7(2), 195-225, 1991; Elman, Cognitive Science, 14(2), 179-211, 1990) - is a feedforward system. SRNs have been essential tools in advancing theories of learning, development, and processing in cognitive science for more than three decades. If SRNs were feedforward systems, there would be pervasive theoretical implications: Anything an SRN can do would therefore be explainable without interaction (feedback).
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- Type II SLAP lesions in the shoulder can be treated through arthroscopic repair or biceps tenodesis, but there's limited data on outcomes post-repair.
- The study aimed to determine the minimal clinically important difference (MCID), Patient Acceptable Symptom State (PASS), and substantial clinical benefit (SCB) for patients who underwent arthroscopic repair for these lesions.
- Results showed that most patients experienced clinically significant improvements post-surgery, with the ASES score yielding the highest rates of SCB and factors like forward flexion positively impacting recovery outcomes.