Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A.

Mono-ADP-ribosyl transferase (mART) proteins are secreted virulence factors produced by several human pathogens, the founding member being diphtheria toxin (DT). Pseudomonas aeruginosa can also secrete a mART toxin, known as exotoxin A (PE), but with an organization of its three functional domains (receptor, translocation, and enzymatic elements) that is opposite to DT. Two additional PE-like toxins (PLTs) have been identified from Vibrio cholerae and Aeromonas hydrophila, suggesting more PLT family members may exist.

Development of Evidence-Based Guidelines for the Integration of Generative AI in University Education Through a Multidisciplinary, Consensus-Based Approach.

Introduction: The introduction highlights the transformative impact of generative artificial intelligence (GenAI) on higher education (HE), emphasising its potential to enhance student learning and instructor efficiency while also addressing significant challenges such as accuracy, privacy, and ethical concerns. By exploring the benefits and risks of AI integration, the introduction underscores the urgent need for evidence-based, inclusive, and adaptable frameworks to guide universities in leveraging GenAI responsibly and effectively in academic environments.

Aims: This paper presents a comprehensive process for developing cross-disciplinary and consensus-based guidelines, based on the latest evidence for the integration of GenAI at European University Cyprus (EUC).

Healthy as a Horse? Characterising the UK and Ireland's Horse Owners, Their Horses, and Owner-Reported Health and Behavioural Issues.

This study focuses on recreational horse owners in the UK and Ireland to explore the relationship between horse characteristics and welfare issues. An online questionnaire was distributed to 1501 horse owners to collect data on the owners, horses, and health/behavioural issues. Most respondents were female (98%), lived in England (56%), and did not insure their horses for veterinary costs (51%).

Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren's disease.

Background: Sjögren's Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the protein-rich aqueous component of tears, and SjD-associated autoimmune dacryoadenitis (AD) may thus alter tear autoantibody composition.

Methods: The presence of tertiary lymphoid structures (TLS) in LG from two murine models of SjD-associated AD, male non-obese diabetic (NOD) and male non-obese insulitis resistant (NOR) mice, were evaluated using immunofluorescence.

'No one cares about the animal like me.' Indian veterinarians' experiences of improving animal welfare through Continuing Professional Development.

Veterinarians are custodians of animal welfare, ensuring practices remain current and effective in the face of the ever-changing demands of the profession. Continuing Professional Development (CPD) is essential for protecting animal welfare, however access to quality CPD is a challenge in many countries. India has one of the fastest growing veterinary industries globally, emphasising the importance of accessible CPD opportunities that are relevant to this setting.