Publications by authors named "J A M van Oers"
Background: In the previously reported SAPS trial (https://clinicaltrials.gov/ct2/show/NCT01139489), procalcitonin-guidance safely reduced the duration of antibiotic treatment in critically ill patients. We assessed the impact of shorter antibiotic treatment on antimicrobial resistance development in SAPS patients.
View Article and Find Full Text PDFBackground: More than 50% of intensive care unit (ICU) survivors suffer from long-lasting physical, psychosocial, and cognitive health impairments, also called "post-intensive care syndrome" (PICS). Intensive care admission during the COVID-19 pandemic was especially uncertain and stressful, both for patients and for their family. An additional risk of developing symptoms of PICS was feared in the absence of structural aftercare for the patient and family shortly after discharge from the hospital.
View Article and Find Full Text PDFArticle Synopsis
- Exonuclease 1 (EXO1) is crucial for DNA repair, replication, and other processes, and its specific roles—enzymatic or scaffolding—are being investigated.
- Research comparing mutant mice with inactive EXO1 (Exo1DA/DA) to completely EXO1-deficient mice (Exo1-/-) reveals that EXO1's enzymatic function is essential for error-free DNA repair, while its scaffolding role is significant in some non-canonical repair pathways.
- Both Exo1DA/DA and Exo1-/- mice show similar cancer risks, highlighting EXO1's complex functions in DNA metabolism and its impact on processes like meiosis and antibody diversification.
Background/objectives: Patients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.
View Article and Find Full Text PDFArticle Synopsis
- Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition that necessitates intensive care, and the study aimed to evaluate whether levels of C-terminal proarginine vasopressin (CT-proAVP) can predict poor outcomes, mortality, and delayed cerebral ischemia (DCI) in patients compared to existing scoring systems.
- The research examined CT-proAVP levels in 100 patients with aSAH and found that higher levels of CT-proAVP were significantly correlated with worse functional outcomes at one year, as well as with mortality within 30 days and one year.
- Though CT-proAVP showed high accuracy for predicting poor outcomes and mortality (with AUC values around 0.84