Publications by authors named "J A M Van Oers"
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup.
Background: In the previously reported SAPS trial (https://clinicaltrials.gov/ct2/show/NCT01139489), procalcitonin-guidance safely reduced the duration of antibiotic treatment in critically ill patients. We assessed the impact of shorter antibiotic treatment on antimicrobial resistance development in SAPS patients.
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- Over 50% of ICU survivors experience "post-intensive care syndrome" (PICS) symptoms, which include physical, psychological, and cognitive impairments, especially amid the stress of COVID-19.
- A quality improvement study aimed to support patients and families transitioning home after ICU treatment by providing structured telephone support (STS) to identify and address PICS symptoms within four weeks of discharge.
- The study found that many patients reported physical symptoms like loss of strength and fatigue, while caregivers highlighted a desire for ongoing care, allowing healthcare providers to adjust follow-up plans based on individual needs.
Article Synopsis
- Exonuclease 1 (EXO1) is crucial for DNA repair, replication, and other processes, and its specific roles—enzymatic or scaffolding—are being investigated.
- Research comparing mutant mice with inactive EXO1 (Exo1DA/DA) to completely EXO1-deficient mice (Exo1-/-) reveals that EXO1's enzymatic function is essential for error-free DNA repair, while its scaffolding role is significant in some non-canonical repair pathways.
- Both Exo1DA/DA and Exo1-/- mice show similar cancer risks, highlighting EXO1's complex functions in DNA metabolism and its impact on processes like meiosis and antibody diversification.
Article Synopsis
- The study examined the impact of obesity on inflammatory biomarkers and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.
- Among 105 patients, 42 were classified as obese, yet no significant differences in inflammatory markers (MR-proADM, CT-proET-1, etc.) were found between those with and without obesity over the first week of illness.
- The findings suggest that obesity does not affect the severity of inflammation or key clinical outcomes like ICU stay, ventilation time, or mortality in these cases.