Publications by authors named "J A Lucy"
Article Synopsis
- Management of immune thrombocytopenia (ITP) in dogs and cats lacks established evidence-based guidelines, leaving treatment decisions largely to clinician discretion.
- The first-line treatment involves immunosuppressive glucocorticoids, with additional therapies such as azathioprine and vincristine used in more severe cases; however, optimal regimens are still unclear.
- A consensus process involving a structured literature review and expert opinions led to the creation of guidelines highlighting the need for further research in ITP treatment options.
Background: Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking.
Objectives: Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) and markers related to bleeding severity, transfusion, and survival of dogs with pITP.
Animals: Ninety-eight thrombocytopenic dogs (58 pITP and 40 sITP).
Article Synopsis
- Pulmonary arterial hypertension (PHT) leads to severe changes in the heart's right ventricle (RV), causing wall thickening, stiffening, and impaired function.
- In a study involving sheep, researchers found that PHT resulted in excessive collagen production and structural changes in the heart, correlating strongly with increased myocardial stiffness.
- Computational modeling indicated that myocardial stiffness is a significant contributor to RV stiffening compared to other mechanisms, highlighting the complexity of PHT impacts on heart function.
Objective: To characterize the frequency and type of bacterial infection by culture- and immunohistochemical (IHC)-based methods and determine the impact of infection on clinical features and survival time in cats with suppurative cholangitis-cholangiohepatitis syndrome (S-CCHS).
Animals: 168 client-owned cats with S-CCHS (cases).
Procedures: Clinical features, bacterial culture results, culture-inoculate sources, and survival details were recorded.
Objective: To characterize clinical, clinicopathologic, and hepatic histopathologic features and outcome for dogs with probable ketoconazole-induced liver injury.
Animals: 15 dogs with suspected ketoconazole-induced liver injury that underwent liver biopsy.
Procedures: Medical record data were summarized regarding signalment, clinical signs, clinicopathologic and hepatic histopathologic findings, concurrent medications, ketoconazole dose, treatment duration, and outcome.