Publications by authors named "J A Lott"
We present experiments on reservoir computing (RC) using a network of vertical-cavity surface-emitting lasers (VCSELs) that we diffractively couple via an external cavity. Our optical reservoir computer consists of 24 physical VCSEL nodes. We evaluate the system's memory and solve the 2-bit XOR task and the 3-bit header recognition (HR) task with bit error ratios (BERs) below 1% and the 2-bit digital-to-analog conversion (DAC) task with a root mean square error (RMSE) of 0.
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- Bacterial ABC toxin complexes consist of three main proteins: TcA, TcB, and TcC, which work together to deliver a toxic "cargo" to target cells; TcA binds and penetrates the cell membrane, while TcB and TcC form a shell around the cargo.
- A new TcC protein structure from Yersinia entomophaga was identified, revealing that inside the TcB-TcC shell, the toxin adopts a disordered state but has areas of local order thanks to the shell's surface.
- When outside the shell, the toxin has a structure similar to the SpvB toxin from Salmonella, suggesting it modifies actin to inhibit its normal function in cell processes.
The alkaline comet assay is frequently used as in vivo follow-up test within different regulatory environments to characterize the DNA-damaging potential of different test items. The corresponding OECD Test guideline 489 highlights the importance of statistical analyses and historical control data (HCD) but does not provide detailed procedures. Therefore, the working group "Statistics" of the German-speaking Society for Environmental Mutation Research (GUM) collected HCD from five laboratories and >200 comet assay studies and performed several statistical analyses.
View Article and Find Full Text PDFObjectives: The primary objective of this study was to determine whether two neurosurgical procedures, deep brain stimulation (DBS) and focused ultrasound (FUS), to treat essential tremor (ET) of the upper limb also reduce vocal tremor (VT) in patients with comorbid dysphonia.
Methods: Twelve patients with ET and concomitant VT scheduled for neurosurgical intervention (FUS or DBS) or returning for follow-up after DBS implantation were assessed. FUS patients were assessed pre- and post-intervention and DBS patients were assessed with the electrodes turned on and off post-implantation.
Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control the size and architecture of the brain and understanding the mechanisms regulating NPCs is crucial to understanding brain developmental disorders.
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