Pediatric Acute Otitis Media Clinical Trials: An Analysis of Diversity.

Objective: This study aims to assess the diversity and equity of pediatric acute otitis media (AOM) trials using ClinicalTrials.gov, focusing on participant demographics and representation to identify gaps in inclusivity and inform strategies for promoting diversity in future pediatric AOM studies.

Study Design: Retrospective analysis.

Cuterebra myiasis with persistent eyelid swelling after larva removal.

Human infection with Cuterebra species is the most common form of endemic myiasis in North America. The authors present a case of a `12-year-old female with left upper eyelid swelling 1 week after visiting a petting farm in Manitoba. A larva was removed with forceps through an eyelid skin pore and identified as Cuterebra sp.

Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

Interleukin-6 (IL-6) is a major pro-inflammatory cytokine that demonstrates a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play a crucial role in metabolic homeostasis and regenerative processes primarily via the canonical STAT3 pathway. Thus, selective modulation of IL-6 signaling may offer a unique opportunity for therapeutic interventions.

Demand for Increased Financial Support to Families of Privately Insured Pediatric Hearing Aid Users.

Purpose: The ability to hear is germane in fostering communiation skills in children and plays a crucial role in their overall wellbeing. Unfortunately, hearing impairment is one of the most common developmental discrepancies in children.

Objective: To describe and evaluate the current legislation surrounding pediatric hearing aid reimbursement and the implications of these policies.

Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI.

An immunocompromised patient was infected by the SARS-CoV-2 variant of interest named Zeta (P.2) in February 2021. More than one year later, he suffered from symptomatic COVID-19 and sequencing revealed the same variant, which accumulated 23 substitutions.