Publications by authors named "J A Krause"

Article Synopsis
  • The discharge of calved ice and subglacial runoff in Disko Bay, home to Sermeq Kujalleq glacier, is expected to influence marine biogeochemistry, particularly affecting the marine silica cycle due to elevated dissolved silica (dSi) from glaciers.
  • The study analyzes silica dynamics in various regions around Disko Bay, finding that land-terminating glaciers show conservative dSi patterns, whereas marine-terminating glaciers significantly alter nutrient distribution through subglacial discharge plumes.
  • The research quantifies contributions to dSi enrichment, highlighting that a large fraction comes from saline water entrainment, with minor contributions from icebergs and amorphous silica dissolution, ultimately adding a small but significant dSi flux to the environment.
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Objective: The goal of this study was to test if a mindfulness-based intervention (MBI) compared to an active control ameliorates the impacts of life stressors on momentary mindfulness and emotion regulation difficulties among adolescents exposed to chronic stressors.

Method: Adolescents exposed to chronic stressors (N = 81, Mage = 13.75 years; 56% boys; 24% Hispanic/Latino, 57% White) were randomized to receive MBI within the context of a community-based mentoring program (MBI + mentoring) or mentoring-alone.

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Article Synopsis
  • The study investigates how the Lapland longspur, a wild arctic-breeding bird, reacts to extreme weather events and what coping strategies it employs.
  • The researchers analyze gene expression changes using RNA-seq to see how environmental stressors like a cold spring and a severe storm impact the bird's stress response, reproductive behaviors, and metabolism.
  • Key findings include the significant up-regulation of the FKBP5 gene in the hypothalamus, which contributes to understanding how the bird adapts to changing climates and provides resources for future genomic studies.
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Human treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most famously, syphilis. Debates on both a common origin for these pathogens and the history of syphilis itself has weighed evidence for the "Columbian hypothesis", which argues for an American origin, against that for the "pre-Columbian hypothesis", which argues for presence of the disease in Eurasia in the Medieval period and possibly earlier. While molecular data has provided a genetic basis for distinction of the typed subspecies, deep evolution of the complex has remained unresolved due to limitations in the conclusions that can be drawn from the sparse paleogenomic data currently available.

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Background: Methods to call, analyze and visualize copy number variations (CNVs) from massive parallel sequencing data have been widely adopted in clinical practice and genetic research. To enable a streamlined analysis of CNV data, comprehensive annotations and good visualizations are indispensable. The ability to detect single exon CNVs is another important feature for genetic testing.

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