Publications by authors named "J A Kimmel"

Article Synopsis
  • Tear fluid is a useful source for biomarker discovery, but challenges like small sample volume and inconsistent collection methods hinder its analysis.
  • The study introduces a new high-throughput method for processing tear fluid using just 0.5 μL, which simplifies handling and reduces processing time compared to traditional approaches.
  • This method achieved a four-fold increase in the number of proteins identified, demonstrating the effectiveness of microcapillary collection and the potential for improved biomarker discovery in tear proteomics.
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Many migratory fishes are thought to navigate to natal streams using olfactory cues learned during early life stages. However, direct evidence for early-life olfactory imprinting is largely limited to Pacific salmon, and other species suspected to imprint show life history traits and reproductive strategies that raise uncertainty about the generality of the salmonid-based conceptual model of olfactory imprinting in fishes. Here, we studied early-life olfactory imprinting in lake sturgeon (), which have a life cycle notably different from Pacific salmon, but are nonetheless hypothesized to home via similar mechanisms.

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Thyroid hormones (TH) are known to play an important role in the growth and development of vertebrates. In fish species, TH regulates the larval-juvenile metamorphosis, and is crucial for development during early life stages. Monitoring the variations in TH levels at different life stages can provide insights into the regulation of metamorphosis and fish development.

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Objectives: Extracorporeal carbon dioxide removal (ECCO 2 R) devices are effective in reducing hypercapnia and mechanical ventilation support but have not been shown to reduce mortality. This may be due to case selection, device performance, familiarity, or the management. The objective of this study is to investigate the effectiveness and safety of a single ECCO 2 R device (Hemolung) in patients with acute respiratory failure and identify variables associated with survival that could help case selection in clinical practice as well as future research.

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Taxon-specific proteins are key determinants defining the biology of all organisms and represent prime drug targets in pathogens. However, lacking comparability with proteins in other lineages makes them particularly difficult to study. In malaria parasites, this is exacerbated by technical limitations.

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