Publications by authors named "J A Kidd"
Chronic kidney disease (CKD) affects 10% of the global population, with increasing prevalence driven by diabetes, hypertension, and aging populations. CKD often progresses asymptomatically, frequently undetected until advanced stages, and may require costly treatments, such as dialysis or transplantation. CKD imposes a substantial financial burden on health care systems, with management costs rising sharply as the disease progresses, underscoring the need for early, cost-effective interventions.
View Article and Find Full Text PDFImportance: Enhanced breast cancer screening with magnetic resonance imaging (MRI) is recommended to women with elevated risk of breast cancer, yet uptake of screening remains unclear after genetic testing.
Objective: To evaluate uptake of MRI after genetic results disclosure and counseling.
Design, Setting, And Participants: This multicenter cohort study was conducted at the University of Southern California Norris Cancer Hospital, the Los Angeles General Medical Center, and the Stanford University Cancer Institute.
Article Synopsis
- Fungal infections are a major global health problem, leading to research focused on finding new antifungal treatments.
- 110 kDa heat shock proteins (Hsp110s) are key proteins in fungi that help maintain cell function, making them a target for antifungal strategies.
- The study highlights 2H as a promising antifungal agent that disrupts Hsp110 activity and shows better effectiveness when taken orally rather than intravenously.
Article Synopsis
- The study examines the impact of mitochondrial sequences found in the nuclear genome (Numts) on analyzing mitochondrial variation in dogs, which can lead to misleading results in disease research.
- Researchers conducted a comprehensive assessment of Numt content across various dog genomes and found 321 Numts present in a widely used genome assembly, with some dating back over 10 million years and shared with other carnivores.
- The findings aim to provide clarity on the confounding effects of Numts in genetic studies and offer a resource to better analyze mitochondrial genetic variations in canines.
Circadian rhythms are important biological contributors to health. Rest activity rhythms (RAR) are emerging as biomarkers of circadian behavior that are associated with chronic disease when abnormal. RAR have not yet been characterized in chronic kidney diseases (CKD).
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