A Role of Inflammation in Charcot-Marie-Tooth Disorders-In a Perspective of Treatment?

Despite the fact that there are published case reports and model work providing evidence of inflammation in Charcot-Marie-Tooth disorders (CMTs), in clinical practice, CMT and inflammatory neuropathies are always classified as two separate groups of disorders. This sharp separation of chronic neuropathies into two groups has serious clinical implications. As a consequence, the patients harboring CMT mutations are practically excluded from pharmacological anti-inflammatory treatments.

Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70.

Cryptorchidism, the absence of one or both testicles in the scrotum, is the most common anomaly of genitourinary tract in males. The pathogenesis of undescended testes is unknown however the role of inflammation, tissue remodeling and oxidative stress is postulated. The aim of this study was to explore the role of HSP-70, MMP-3, MMP-17 and IL-8 in possible pathogenic pathways connected with cryptorchidism.

Outer Membrane Vesicles Formed by Clinical Strains May Be Incorporated into the Outer Membrane of Other Cells and Demonstrate Lytic Properties.

Outer membrane vesicles (OMVs) are extracellular structures, ranging in size from 10 to 300 nm, produced by Gram-negative bacteria. They can be incorporated into the outer membrane of a recipient's cells, which may enable the transfer of substances with lytic properties. Due to the scarce information regarding the OMVs produced by , the aim of this study was to test the blebbing abilities of the clinical O77 and O78 strains and to determine the blebs' interactions with bacterial cells, including their possible bactericidal activities.

Sex-dependent responses to acute sodium bicarbonate different dose treatment: A randomized double-blind crossover study.

Objectives: This study quantified blood bicarbonate (HCO) kinetics and gastrointestinal upset to determine the gender-related ergogenic potential of sodium bicarbonate (0.15-, 0.25- and 0.