Publications by authors named "J A Judd"
Background: The 3xTg-AD transgenic mouse model of Alzheimer's disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition.
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- Glyphosate usage has risen significantly in the U.S. since 1996, with research showing it can accumulate in the brain and invoke neuroinflammation, potentially influencing neurodegenerative disorders like Alzheimer's Disease (AD).
- The study involved giving varied doses of glyphosate to both Alzheimer's model mice and control mice, revealing that glyphosate and its metabolite remained detectable in brain tissue even after a recovery period.
- Results indicated that glyphosate exposure led to worsened cognitive function in AD mice, along with significant increases in brain plaque formation, tau protein abnormalities, and persistent inflammatory markers in both mouse groups.
Background: Exercise rehabilitation programmes are important for long-term health and wellbeing among people with cardiac and pulmonary diseases. Despite this, many people struggle to maintain their physical activity once rehabilitation ends. This repeated measures study tracked changes in physical activity behaviour and motivation during and after completing a community-based exercise rehabilitation programme.
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- The study aims to analyze mental health-related hospitalizations among adolescents aged 12-17 in South Australia in relation to their prior contact with the child protection system when they were younger (0-11 years).
- Using data from various linked administrative sources, the researchers highlight how the extent of contact with child protection services correlates with the likelihood of mental health hospitalizations.
- Results show that the rate of hospitalization for mental health issues increases significantly with each level of child protection contact, revealing a concerning trend where more severe interactions with child services are associated with higher hospitalization rates for mental health disorders.