GUIDELINE-DIRECTED MEDICAL THERAPY FOR HEART FAILURE: REAL-WORLD EVIDENCE IN ONE LATIN-AMERICAN CENTER.

Background: Despite recommendations from clinical practice guidelines to initiate four drug classes in patients with heart failure (HF) with reduced ejection fraction, information on real-world implementation remains limited. This study evaluated the medications initiated and titrated, the time until the optimal treatment tolerated, pharmacological profiles, patient's adherence, and causes of non-use of guideline directed-medical therapy (GDMT) in a cohort of patients with HF.

Methods: A retrospective cohort study was conducted on patients treated in a heart failure program in Colombia.

In vivo Differential Effects of Extractable and Non-Extractable Phenolic Compounds from Grape Pomace on the Regulation of Obesity and Associated Metabolic Alterations.

Grape pomace (GP) is a by-product rich in phytochemicals, including extractable polyphenols (EPPs) and non-extractable polyphenols (NEPPs), which have distinct metabolic fates that may affect their biological activities. The benefits of GP have been reported in relation to obesity and its comorbidities, particularly when administered preventively focusing on EPPs. Therefore, the aim of this study was to investigate the effects of EPPs and NEPPs from GP as a treatment for obesity and its associated metabolic alterations.

Nursing Skills in the Care of Patients With Respiratory Stomas in Hospitals With and Without Advanced Practice Tracheostomy Service.

Aims: To identify whether there are differences in knowledge regarding the management of patients with respiratory stomas among nurses working in hospitals with an advanced practice tracheostomy service compared to those without it.

Design: Descriptive, cross-sectional, comparative, analytical survey study.

Method: The study was conducted from January to March 2023 in four tertiary care hospitals, two of which have an advanced practice tracheostomy service.

Rare earth element (REEs) imprints and provenance of wetland sediments from Oaxaca coast, Mexico.

REEs in wetland sediments from the Oaxaca coast in southern Mexico were used to infer the sources and depositional processes by involving both the geochemical characteristics and geostatistical approaches. Statistically strong positive correlation between REEs confirmed similar origin in all the cores. Light REEs (LREEs) represented >84 % of ΣREE mean concentrations varies between 47.

Addition of microbial consortium to the rice straw biomethanization: effect on specific methanogenic activity, kinetic and bacterial community.

The biomethanization of lignocellulosic wastes remains an inefficient and complex process due to lignin structures that hinder the hydrolysis step, therefore, some treatments are required. This work describes the addition of an enriched microbial consortium in the biomethanization of rice straw. The experiment was carried out in lab batch reactors following two strategies: (i) pretreatment of rice straw for 48 h using the enriched microbial consortium (dilution 1:100), and (ii) addition of this enriched microbial consortium (dilution 1:100) directly to the anaerobic reactors (bioaugmentation).