Publications by authors named "J A Ingelfinger"
Renal hedgehog interacting protein (Hhip) activates sodium-glucose cotransporter 2 (Sglt2) expression and promotes tubular senescence in murine diabetic kidney disease (DKD), yet its underlying mechanism(s) are poorly understood. Here we study the effect of the SGLT2 inhibitor, canagliflozin on tubulopathy (fibrosis and apoptosis) in Akita/Hhip-transgenic (Tg) mice with overexpression of Hhip in their renal proximal tubular cells (RPTCs) and its relevant mechanisms. The DKD-tubulopathy with pronounced Sglt2 expression was aggravated in the kidney of Akita/Hhip-Tg cf.
View Article and Find Full Text PDFThe role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion of angiotensinogen (Agt; RT-Agt-/-) in both Akita and streptozotocin (STZ)-induced mouse model of diabetes. Both Akita RT-Agt-/- and STZ-RT-Agt-/- mice exhibited significant attenuation of glomerular hyperfiltration, urinary albumin/creatinine ratio, glomerulomegaly and tubular injury.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the link between elevated systolic blood pressure (SBP) and neurocognitive performance in adolescents, focusing on measures like auscultatory SBP and ambulatory SBP, along with cardiovascular health risk indicators.
- It involved 365 adolescents, averaging 15.5 years old, from various academic medical centers in the U.S., analyzing their cognitive abilities like nonverbal IQ and attention, considering factors like maternal education.
- Results showed that higher SBP corresponded to lower nonverbal IQ and verbal attention scores, indicating that even slight elevations in blood pressure can negatively affect adolescent cognitive functions, suggesting a need for further research on these implications for clinical care.