Publications by authors named "J A Ihalainen"

Background: Early in the COVID-19 pandemic, convalescent plasma (CP) emerged as a potentially effective treatment neutralising SARS-CoV-2. Early CP therapy with high neutralising antibody (NAb) titre may benefit COVID-19 outpatients and, in sufficient quantities even some hospitalised patients. This study details the process of setting up a CP bank, containing high- and low-titre CP for a clinical trial.

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Introduction: This observational study investigated: (1) potential changes in female football players' in-season training load, intensity and physical performance, and (2) if in-season accumulated training load, intensity, or their progression are associated to changes in physical performance.

Methods: Thirty-five national level female players (∼21 years,  = 35) from three top-teams of the Finnish national league participated. Players performed tests at the beginning and at the end of the 27-week in-season.

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Article Synopsis
  • Recent research indicates that the ability to maintain physiological characteristics might play a key role in endurance performance, leading to a study on the effects of low-intensity exercise on lactate threshold and sex differences in fatigue.
  • In the study, 31 recreational runners (15 females) underwent treadmill testing and a 90-minute low-intensity exercise session, with measurements taken for lactate thresholds, heart rate, and other physiological parameters.
  • The results showed significant decreases in lactate threshold for both sexes during the exercise, with a notable correlation found between changes in heart rate variability (DFA-a1) and lactate threshold, suggesting DFA-a1 might serve as an indicator of endurance capacity.
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  • Low energy availability (LEA) is prevalent in female athletes and may disrupt sex hormones, potentially affecting cholesterol metabolism and increasing cardiovascular disease risk.
  • A study involving Finnish female athletes found that a significant number reported symptoms of LEA, with 41% scoring high on the LEAF-Q questionnaire.
  • Higher scores on the LEAF-Q and Eating Disorder Examination Questionnaire Short (EDE-QS) were linked to increased LDL cholesterol levels, particularly among those in sports that prioritize leanness.
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Introduction: Resting energy expenditure (REE) may fluctuate during the menstrual cycle (MC), due to the physiological effects of estradiol (E2) and progesterone. This study examined changes in REE and metabolic hormones (leptin, ghrelin, thyroid hormones), and dietary intake in two hormonally distinct groups, naturally menstruating women (NoOC) and women using monophasic combined oral contraceptives (COC).

Methods: Measurements included REE by indirect calorimetry, body composition by bioimpedance, and blood samples for hormone analysis in the early follicular and midluteal phases of the MC in the NoOC group ( n = 38) or the active and inactive phases of the COC cycle (COC; n = 19).

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