Severe nephrotoxicity during high-dose methotrexate administration in an adolescent with acute lymphoblastic leukemia.

High-dose methotrexate is an effective and safe therapy. It is included in the treatment regimens of various hematologic and oncologic diseases. The acute and severe toxicity of this chemotherapeutic agent is unusual.

IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors.

Background: Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted with T cells expressing chimeric antigen receptors (CARs).

Methods: To determine the expression of the oncofetal version of tenascin C (TNC) encoding the C domain (C.

[Implementing a strategy to manage frequent emergency room visits in a district of Barcelona].

Visits to hospital emergency departments by patients with multimorbidity, complex chronic conditions, and frailty are becoming an increasing challenge. A territorial strategy has been developed, based on automated preselection lists, a nurse case manager with specialized experience, and a multi-level territorial referral consensus. The feasibility of this approach has been demonstrated, with 368 alerts detected, 85% of which were well-selected.

3-D intrinsic attenuation tomography using ambient seismic noise applied to La Palma Island (Canary Islands).

The potential of the island of La Palma (Canary Islands) to host geothermal resources is very high, mainly due to its high volcanic activity. The primary goal of this study is to get a tridimensional image of the seismic intrinsic attenuation using ambient seismic noise and to identify anomalies that may be linked to active geothermal reservoirs on La Palma island. For this purpose, we developed a new Ambient Noise Attenuation Tomography (ANAT) technique, which uses seismic ambient noise for imaging intrinsic attenuation in 3-D at a local scale down to 5 km depth.