Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays.

Individually rare, large copy number variants (CNVs) contribute to genetic vulnerability for schizophrenia. Unresolved questions remain, however, regarding the anticipated yield of clinical microarray testing in schizophrenia. Using high-resolution genome-wide microarrays and rigorous methods, we investigated rare CNVs in a prospectively recruited community-based cohort of 459 unrelated adults with schizophrenia and estimated the minimum prevalence of clinically significant CNVs that would be detectable on a clinical microarray.

Incremental effects of comorbidity on quality of life in patients with psoriatic arthritis.

Objective: To assess the added effect of comorbidity on quality of life (QOL) in psoriatic arthritis (PsA).

Methods: Between 2006 and 2012, 631 patients were recruited from the University of Toronto PsA Clinic. Using the clinical database, we ascertained the frequency of 15 comorbidities.

Rethinking the reference collection: exploring benchmarks and e-book availability.

Librarians in the Health Sciences Library System at the University of Pittsburgh explored the possibility of developing an electronic reference collection that would replace the print reference collection, thus providing access to these valuable materials to a widely dispersed user population. The librarians evaluated the print reference collection and standard collection development lists as potential benchmarks for the electronic collection, and they determined which books were available in electronic format. They decided that the low availability of electronic versions of titles in each benchmark group rendered the creation of an electronic reference collection using either benchmark impractical.

Underestimating physical function gains: comparing FIM motor subscale and interRAI post acute care activities of daily living scale.

Objective: To investigate the construct validity of the activities of daily living (ADLs) sections of 2 major systems developed to measure functional ability in rehabilitation settings. Health assessment systems can inform care planning as well as policy decision-making on service effectiveness. Frailty, comorbidity, and heterogeneity make it difficult to accurately measure health outcomes for older adults.

Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.

There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the NOSA1P gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of NOSA1P risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval)=1.