Publications by authors named "J A Hollenbach"
Killer-cell immunoglobulin-like receptors (s) are essential components of the innate immune system found on the surfaces of natural killer (NK) cells. The s encoding genes are located on chromosome 19q13.4 and are genetically diverse across populations.
View Article and Find Full Text PDFThis article investigates the short- and long-term impacts of retirement on loneliness using panel data from the Survey of Health, Aging, and Retirement in Europe. To identify causal effects, we exploit differences in retirement rules across and within countries and use retirement thresholds in an instrumental variable setting. On average, we find that entering retirement leads to a reduction in loneliness in the long run and no clear effect in the short run.
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- The human major histocompatibility complex (MHC) has high genetic diversity, making traditional reference-based alignment methods for DNA sequence assembly less effective.
- MHConstructor is a new tool that uses a short-read, de novo assembly algorithm specifically for MHC data, allowing for improved assembly in large population studies.
- This pipeline is unique in offering a reproducible, alignment-free method for analyzing MHC sequences, making it more accessible for researchers.
Article Synopsis
- Questions remain about the role of race and geographic ancestry in biomedical research, particularly how they can enhance matching algorithms for human leukocyte antigen (HLA) in stem cell transplants from donor registries.
- Analysis of self-reported racial and ancestral data from over 100,000 U.S. bone marrow donors shows discrepancies among these measures; using both race and geographic ancestry together yields the best fit for HLA genetic ancestry.
- The findings suggest that while direct matching for transplants doesn't use these data, incorporating both race and geographic ancestry is valuable for improving predictions of HLA compatibility in donor registries.
CD8+ T cells are the dominant lymphocyte population in multiple sclerosis (MS) lesions where they are highly clonally expanded. The clonal identity, function, and antigen specificity of CD8+ T cells in MS are not well understood. Here we report a comprehensive single-cell RNA-seq and T cell receptor (TCR)-seq analysis of the cerebrospinal fluid (CSF) and blood from a cohort of treatment-naïve MS patients and control participants.
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