Publications by authors named "J A Halliwell"
Article Synopsis
- Classical systems allow measurements without causing disturbance, while quantum systems do not, particularly in the context of gravity.
- The proposed experimental setup involves multiple interferometers to measure a gravitational field created by a spatial superposition, aiming to demonstrate nonclassical effects.
- This test is unique as it doesn't rely on specific nonclassical gravity forms or entanglement, and it can detect quantum measurement disturbance regardless of decoherence rates, making it device independent.
The timing of DNA replication in mammals is crucial for minimizing errors and influenced by genome usage and chromatin states. Replication timing in the newly formed mammalian embryo remains poorly understood. Here, we have investigated replication timing in mouse zygotes and 2-cell embryos, revealing that zygotes lack a conventional replication timing program, which then emerges in 2-cell embryos.
View Article and Find Full Text PDFWhole slide imaging (WSI) of pathology glass slides using high-resolution scanners has enabled the large-scale application of artificial intelligence (AI) in pathology, to support the detection and diagnosis of disease, potentially increasing efficiency and accuracy in tissue diagnosis. Despite the promise of AI, it has limitations. 'Brittleness' or sensitivity to variation in inputs necessitates that large amounts of data are used for training.
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- Human pluripotent stem cells (hPSCs) hold potential for medical applications, but they often acquire genetic changes that might pose safety risks during culture and therapy.
- Specifically, about 20% of hPSC lines exhibit the amplification of 20q11.21, which provides a survival advantage but may lead to oncogenic risks that are not fully understood.
- Research using human embryonic stem cells in mice shows that those with the 20q11.21 alteration had higher engraftment success and caused more severe lesions, highlighting the need for genetic screening of hPSCs prior to therapeutic use.
Human pluripotent stem cells (hPSCs) can be grown in culture indefinitely, making them a valuable tool for use in basic biology, disease modeling, and regenerative medicine. However, over prolonged periods in culture, hPSCs tend to acquire genomic aberrations that confer growth advantages, similar to those seen in some cancers. Monitoring the genomic stability of cultured hPSCs is critical to ensuring their efficacy and safety as a therapeutic tool.
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