Publications by authors named "J A Haggstrom"
Assessing the pathogenicity of a disease-associated genetic variant in animals accurately is vital, both on a population and individual scale. At the population level, breeding decisions based on invalid DNA tests can lead to the incorrect inclusion or exclusion of animals and compromise the long-term health of a population, and at the level of the individual animal, lead to incorrect treatment and even life-ending decisions. Criteria to determine pathogenicity are not standardized, i.
View Article and Find Full Text PDFArticle Synopsis
- Federated networks enhance data privacy by allowing analysis without transferring sensitive data, supporting trustworthy data analysis in healthcare research.
- The International COVID-19 Data Alliance (ICODA) tested a federated network with partners to analyze data from the International Perinatal Outcome in the Pandemic (iPOP) Study, facing both challenges and benefits in the process.
- Establishing these networks requires significant investment and planning for technology and governance, which can lead to powerful collaborative research opportunities using health data from various countries.
Background: Anastomotic leakage after rectal cancer surgery is linked to reduced survival and higher recurrence rates. While an aggravated inflammatory response may worsen outcomes, few studies have explored the combined effects of leakage and inflammation.
Methods: This is a retrospective multicenter cohort study including patients operated with anterior resection for rectal cancer in Sweden during 2014-2018.
Background And Aims: The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
View Article and Find Full Text PDF