Prospective Trial of Biomarker-Guided Surveillance for HPV-positive Oropharynx Cancer Using Plasma Tumor Tissue Modified Viral HPV DNA.

Background: Observational studies suggest circulating tumor HPV DNA may facilitate early detection of recurrent HPV-positive oropharynx cancer (OPC). We prospectively investigated whether biomarker-guided surveillance detects recurrence sooner than standard-of-care.

Patients And Methods: We enrolled patients evaluated for HPV-positive OPC at a single center 11/2020-4/2023 undergoing curative-intent treatment in a single-arm cohort study.

Multidimensional assessment of exertional dyspnea in young healthy males and females who select unsatisfied inspiration at peak exercise.

Historically, it was thought that healthy humans predominantly described their breathing as a sense of increased work or effort (W/E) during maximal exercise. However, emerging data shows that many healthy adults select unpleasant dyspnea descriptors such as "unsatisfied inspiration" (UI), with relatively more females selecting UI than males. We hypothesized that males and females who select UI would report higher dyspnea intensity ratings during exercise; select more distressing dyspnea qualities post-exercise; and have greater inspiratory constraints than those who do not.

Predictors of Physician Agreement With Radiologist-Recommended Follow-up Imaging.

Objective: Although recommendations for additional imaging are common in radiology reports, completion of follow-up imaging does not always occur, which could reflect disagreement between radiologist and referring provider. We assessed how frequently referring providers agree with radiologists' follow-up recommendations, reasons for disagreement, and factors associated with radiologist-referring provider agreement.

Methods: This institutional review board-exempt, retrospective study was performed at a large academic center.

Patient Photograph Association With Radiologist Recommendations for Additional Imaging.

Objective: Assess whether display of a patient photograph in the electronic health record (EHR) alongside head and neck CT or MRI radiology examinations is associated with recommendations for additional imaging (RAI) and whether self-reported race modifies that association.

Methods: This multi-institution health care system retrospective observational study from June 1, 2021 to May 31, 2022 included all patients with a head/neck CT or MRI report. We investigated association of photograph with RAIs using mixed-effects models adjusting for age, sex, complexity score, race, and area deprivation index while conditioning on patient and radiologist.

The effects of endurance training on muscle oxygen desaturation during incremental exercise tests: a systematic review and meta-analysis.

Objective: Minimum muscle oxygen saturation (SmOmin) measured via near-infrared spectroscopy (NIRS) is a common measure during incremental exercise testing (IET). Our objective was to determine the effects of pre-to-post endurance training on SmOmin (ΔSmOmin) during an IET, using a meta-analysis.

Data Sources: MEDLINE, EMBASE, and SPORTDiscus.