Publications by authors named "J A Groves"
Bruton's tyrosine kinase (BTK) is a major drug target in immune cells. The membrane-binding pleckstrin homology and tec homology (PH-TH) domains of BTK are required for signaling. Dimerization of the PH-TH module strongly stimulates the kinase activity of BTK in vitro.
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- * The study introduces a method using fluorescent labeling and advanced imaging techniques to categorize sEVPs from the same cell type into seven distinct subpopulations, revealing differences in composition and features.
- * Findings suggest that this new characterization approach can help differentiate sEVPs from cancerous and normal cells, potentially improving diagnostic and therapeutic strategies related to these vesicles.
Article Synopsis
- The WHO African Region is significantly impacted by malaria, contributing to 94% of global cases, prompting research on detecting Plasmodium RNA in blood donors from Cameroon, Madagascar, and Mali.
- Testing involved analyzing whole blood samples using a specialized assay to identify reactive results, with findings revealing varying rates of Plasmodium repeat reactivity across the countries.
- The study concluded that detecting Plasmodium RNA and related antibodies can enhance safety measures in blood donations and help tackle malaria risks effectively.