Publications by authors named "J A Gribben"
Autologous stem-cell transplantation (ASCT) is standard therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), but many patients are either ineligible or unable to receive it. This retrospective study characterized outcomes in R/R LBCL, delineated by eligibility for, and receipt of, ASCT. Median progression-free survival (PFS) and event-free survival (EFS) for patients undergoing ASCT were 35.
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- Acute myeloid leukaemia (AML) is a serious bone marrow cancer that can be difficult to treat, especially in patients with FLT3 mutations who often don't respond well to current therapies like midostaurin combined with intensive chemotherapy (MIC).
- Researchers analyzed samples from 47 patients with FLT3-MP AML using advanced mass spectrometry and machine learning to find better predictive biomarkers for treatment response, leading to the development of a new model called MPhos.
- The MPhos model showed an impressive predictive accuracy in separate validation cohorts, outperforming the existing FLT3-based method, which could significantly improve treatment decision-making in AML patients.
Introduction: The introduction of Bruton's tyrosine kinase (BTK) inhibitors significantly improved the management of chronic lymphocytic leukemia (CLL). However, BTK carry the risk of cardiotoxicity, which is not only limited to atrial fibrillation. .
View Article and Find Full Text PDFBackground: Hypoglycaemia is the primary manifestation of all the hepatic types of glycogen storage disease (GSD). In 2008, Glycosade, an extended-release waxy maize cornstarch, was reported as an alternative to uncooked cornstarch (UCCS) which could prolong the duration of fasting in the GSD population. To date, there has been minimal published experience in (a) young children, (b) the ketotic forms of GSD, and (c) with daytime dosing.
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