Publications by authors named "J A Greenwald"
Article Synopsis
- - Dashboards in health systems help track and improve serious illness conversation (SIC) quality indicators, but the effectiveness and challenges of these dashboards are still not fully understood.
- - Interviews with palliative care leaders revealed that while dashboards can enhance data transparency and support clinician practice changes, they rely heavily on structured documentation that clinicians don't always use effectively.
- - Key challenges include ensuring the reliability of data, securing necessary resources for dashboard maintenance, and integrating patient-centered outcome measures, which may hinder the overall effectiveness of these tools in practice.
This is a systematic review and meta-analysis evaluating the uptake of cascade genetic testing for hereditary breast and ovarian cancer syndrome. Among 30 studies included for meta-analysis, the uptake of cascade genetic testing was 33% (95% CI 25%-42%), with higher uptake rates among females compared with male relatives, and among first-degree compared with second-degree relatives. These findings indicate suboptimal uptake of cascade genetic testing among people at risk for hereditary breast and ovarian cancer syndrome, representing a missed opportunity for cancer prevention and early detection.
View Article and Find Full Text PDFReversible and irreversible amyloids are two diverging cases of protein (mis)folding associated with the cross-β motif in the protein folding and aggregation energy landscape. Yet, the molecular origins responsible for the formation of reversible vs irreversible amyloids have remained unknown. Here we provide evidence at the atomic level of distinct folding motifs for irreversible and reversible amyloids derived from a single protein sequence: human lysozyme.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the structures of α-synuclein fibrils linked to neurodegenerative disorders, revealing how variations in pH and buffer conditions impact the selection of different fibril polymorphs.
- The researchers found that within the physiological pH range, polymorph selection is influenced by secondary nucleation mechanisms, even when seeds are present.
- Additionally, two new polymorphs were identified, highlighting the importance of environmental factors like pH in understanding amyloid aggregation and its implications for disease-relevant research.