Publications by authors named "J A Gow"
Article Synopsis
- Delirium is a serious neuropsychiatric condition seen often in intensive care and post-surgery, leading to longer hospital stays and higher mortality/morbidity rates.
- A systematic review analyzed 1746 studies on delirium biomarkers from 2000-2023, resulting in the inclusion of 78 studies emphasizing proteomic signatures related to the condition.
- The review identified 313 proteins, with a focus on 13 key proteins (like IL-6, CRP, and TNF-a) that show a significant link to delirium, highlighting the need for more research to better understand these biomarkers for diagnosis and treatment.
Objective: To improve the understanding of the natural disease progression of ()associated X-linked retinitis pigmentosa (XLRP).
Design: A multicenter, prospective, observational natural history study over 24 months.
Participants: Male participants aged ≥7 years with a pathogenic variant in the gene, a best-corrected visual acuity (BCVA) score of ≥34 ETDRS letters, and a mean 68-loci retinal sensitivity (assessed by microperimetry) of 0.
Background: The purpose of this study was to investigate the association between dementia, chronic pain and self-care limitations. Additionally, the study sought to explore the relationship of co-occurring dementia and chronic pain with self-care limitations.
Methods: Cross-sectional data derived from the Survey of Disability, Ageing and Carers (SDAC) was used to conduct this study.
Background: The distributional effects of cognitive impairment on inequalities in health-related quality of life (HRQoL) are not well studied. This relationship has not been studied in any Australian health inequality literature. Therefore, this study aims to examine how cognitive impairment affects the distribution of HRQoL across various socio-economic classes amongst older Australians.
View Article and Find Full Text PDFBackground: Delirium and Alzheimer's disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia.
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