Hypertension is the most prevalent modifiable risk factor for stroke and is associated with worse functional outcomes. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid (SAHA) modulates gene expression and has emerged as a promising therapeutic approach to reduce ischaemic brain injury. Here, we have tested the therapeutic potential of SAHA administered during reperfusion in adult male spontaneously hypertensive (SHR) rats subjected to transient middle cerebral artery occlusion (tMCAO; 90 min occlusion/24 h reperfusion).
View Article and Find Full Text PDFBol Med Hosp Infant Mex
April 2019
Background: The backbone of food allergy treatment is the restriction of causative foods. These interventions have shown that children who restrict the consumption of basic foods have a higher risk of malnutrition. The aim of the study was to identify the nutritional status of patients with elimination diet, characterizing their anthropometric indexes and identifying the percentage of patients in the group with true food allergies.
View Article and Find Full Text PDFJ Sports Med Phys Fitness
December 2011
Aim: The aim of this study was to analyze, through echocardiography, the structure and functional cardiac profile of national category Spanish soccer referees.
Methods: The sample consisted of 54 licensed referees, who belonged to the Football Inter-Insular Federation of Las Palmas. The sample presented a mean age of 28.
The first objective of the present study was to examine the accuracy of offside judgements of assistant referees during the 2006 World Cup and to compare overall results with performances of assistant referees during the 2002 World Cup. Second, we also examined underlying mechanisms leading to incorrect decisions. According to the definition used for the 2002 World Cup, the results revealed a decrease in the number of incorrect flag signals during the 2006 (24/240 or 10.
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