Publications by authors named "J A Funder"
Transglutaminase 2 (TG2) is an enzyme with multiple conformations. In its open conformation, TG2 exhibits transamidase activity linked to fibrosis, arterial remodeling, and endothelial dysfunction, a process enhanced by high glucose in endothelial cells. However, the closed conformation of TG2 contributes to transmembrane signaling and nitric oxide (NO)-dependent vasorelaxation.
View Article and Find Full Text PDFBackground: Postoperative ileus (POI), characterized by absent gastrointestinal motility, is a frequent complication following major abdominal surgery, with no current effective treatment possibilities. For further research in the treatment of this condition, we aimed to establish a porcine model of POI.
Methods: A total of 12 Landrace pigs, weighing 60 kg, were included.
Background: In many practices, the screening for primary aldosteronism relies on a single-blood draw for plasma aldosterone concentration (PAC) and plasma renin activity (PRA) to establish an aldosterone-to-renin ratio (ARR). ARR levels vary between expert centers and repeated assays in the same individual, emphasizing the potential variability of this screening approach. A suppressed PRA to <1 ng/mL per h has been proposed as an alternative test to the ARR.
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- The study aimed to create global benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary rectal cancer (LARC) and recurrent rectal cancer (LRRC), drawn from data at specialized centers.
- Researchers conducted a retrospective analysis of 763 patients across 16 experienced centers from 2018 to 2023, focusing on a subgroup of 544 lower-risk patients to establish ten key outcome benchmarks.
- The findings set specific targets for major complication rates, mortality rates, and R0 resection rates that can guide surgical quality assessments and improvements in PE procedures worldwide.
Recurrence and Survival Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Synchronous and Metachronous Peritoneal Metastases of Colorectal Origin.
Cancers (Basel)
February 2024
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved the 5-year survival for colorectal cancer (CRC) patients with peritoneal metastases (PM). Little is known about recurrence patterns and recurrence rates between synchronous (S) and metachronous (M) PM following CRS+HIPEC. We aimed to describe the recurrence patterns, overall survival (OS) and disease-free survival (DFS) in S-PM and M-PM patients after complete CRS+HIPEC.
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