Transfer of and increases 3D growth and invasiveness in recipient cancer cells.

Aim: Extracellular communication via the transfer of vesicles and nanoparticles is now recognized to play an important role in tumor microenvironment interactions. Cancer cells upregulate and secrete abundant levels of and that can alter gene expression in donor and recipient cells. In this study, we sought to identify targets of and and conclusively demonstrate that microRNAs (miRNAs) can be functionally transferred from donor to recipient cells.

Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries.

Longitudinal patient registries generate important evidence for advancing clinical care and the regulatory evaluation of health-care products. Most national registries rely on data collected as part of routine clinical encounters, an approach that does not capture real-world, patient-centred outcomes, such as physical activity, fatigue, ability to do daily tasks, and other indicators of quality of life. Digital health technologies that obtain such real-world data could greatly enhance patient registries but unresolved challenges have so far prevented their broad adoption.

Cyanobacterial Cultures, Cell Extracts, and Individual Toxins Decrease Photosynthesis in the Terrestrial Plants and .

Cyanobacterial harmful algal blooms (cHABs) are increasing due to eutrophication and climate change, as is irrigation of crops with freshwater contaminated with cHAB toxins. A few studies, mostly in aquatic protists and plants, have investigated the effects of cHAB toxins or cell extracts on various aspects of photosynthesis, with variable effects reported (negative to neutral to positive). We examined the effects of cyanobacterial live cultures and cell extracts ( or ) and individual cHAB toxins (anatoxin-a, ANA; beta-methyl-amino-L-alanine, BMAA; lipopolysaccharide, LPS; microcystin-LR, MC-LR) on photosynthesis in intact plants and leaf pieces in corn () and lettuce ().

Development and Validation of Claims-Based Algorithms for Conjunctivitis and Keratitis.

Background: Ocular surface disorders have been reported among patients with various medical conditions, including atopic dermatitis (AD). Nonetheless, validated algorithms to identify conjunctivitis and keratitis in claims data are lacking.

Objective: Develop validated, claims-based algorithms for conjunctivitis and keratitis among patients with AD using medical records.