Publications by authors named "J A Foote"
Pancreatic ductal adenocarcinoma (PDAC) has a minimal (<15%) 5-year existence, in part due to resistance to chemoradiotherapy. Previous research reveals the impact of paricalcitol (P) and hydroxychloroquine (H) on altering the lysosomal fusion, decreasing stromal burden, and triggering PDAC to chemotherapies. This investigation aims to elucidate the molecular properties of the H and P combination and their potential in sensitizing PDAC to gemcitabine (G).
View Article and Find Full Text PDFRAS is a common driver of cancer that was considered undruggable for decades. Recent advances have enabled the development of RAS inhibitors, but the efficacy of these inhibitors remains limited by resistance. Here, we developed a pan-RAS inhibitor, ADT-007, that binds nucleotide-free RAS to block GTP activation of effector interactions and MAPK/AKT signaling, resulting in mitotic arrest and apoptosis.
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- ADT-1004 is a new oral prodrug that effectively inhibits tumor growth and RAS activation in pancreatic ductal adenocarcinoma (PDAC) models without causing significant toxicity.
- It works by blocking ERK phosphorylation in tumor cells, showing effectiveness against various KRAS mutations and increasing immune cell presence in the tumor microenvironment.
- ADT-1004’s broad antitumor activity and selectivity for KRAS mutant tumors make it a promising candidate for clinical trials in treating PDAC, potentially outperforming existing KRAS inhibitors.
Assessment of Education and Management of Endometriosis Among Colorectal Surgeons and Residents.
J Minim Invasive Gynecol
December 2024
Study Objective: To identify the type of endometriosis education and surgical training colorectal surgery residents are exposed to during training. To determine the current surgical management of endometriosis among recently graduated colorectal surgeons and their level of comfort.
Design: A qualitative cross-sectional study was performed.
Artificial intelligence (AI) applications to medical care are currently under investigation. We aimed to evaluate and compare the quality and accuracy of physician and chatbot responses to common clinical questions in gynecologic oncology. In this cross-sectional pilot study, ten questions about the knowledge and management of gynecologic cancers were selected.
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