Publications by authors named "J A Esteban"
Aims: Electromagnetic induction heating has demonstrated in vitro antibacterial efficacy over biofilms on metallic biomaterials, although no in vivo studies have been published. Assessment of side effects, including thermal necrosis of adjacent tissue, would determine transferability into clinical practice. Our goal was to assess bone necrosis and antibacterial efficacy of induction heating on biofilm-infected implants in an in vivo setting.
View Article and Find Full Text PDFThe impact of prior unsuccessful debridement, antibiotics, and implant retention (DAIR) procedures on subsequent revisions is uncertain, with conflicting evidence. Despite 85% consensus against the second DAIR procedure following the 2018 International Consensus Meeting, a 2020 study reported high success rates for the aforementioned second DAIR procedure. We conducted a multicenter observational study reviewing data from patients with failed DAIR procedures between 2005 and 2021.
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- - Niemann-Pick disease Type C (NPC) is linked to mutations in the NPC1 protein that disrupt cholesterol transport, leading to lipid buildup and psychiatric problems.
- - In an NPC mouse model, researchers discovered that mGluR (metabotropic glutamate receptors) accumulate abnormally inside cells, affecting their function and leading to changes in long-term depression (a form of synaptic plasticity).
- - Treatment with the mGluR antagonist CTEP lowered mGluR-related issues and improved psychiatric symptoms, suggesting alterations in mGluR play a role in NPC and offering potential new therapies for affected individuals.
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- Deficiencies in the electron transport chain (ETC) contribute to mitochondrial diseases, but the reasons for different cellular sensitivities to this disruption are not fully understood.
- This study finds that under ETC inhibition, a different type of tricarboxylic acid (TCA) cycle is activated to maintain malate levels and produce NADPH, which is crucial for cell function.
- The research highlights how astrocytes, which express specific enzymes like Pyruvate carboxylase (PC) and ME1 more than neurons, demonstrate greater resilience to ETC issues, suggesting potential therapeutic strategies for managing mitochondrial diseases.
New antibiofilm strategies for the management of nontuberculous mycobacteria diseases.
Expert Opin Pharmacother
October 2024
Introduction: Nontuberculous mycobacteria (NTM) represent a group of microorganisms comprising more than 190 species. NTM infections have increased recently, and their treatment is a major challenge because to their resistance to conventional treatments. This review focuses on innovative strategies aimed at eradicating NTM biofilms, a critical factor in their resistance.
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