Publications by authors named "J A Ellerton"
Article Synopsis
- The study assesses the effectiveness of a dual checkpoint inhibition therapy (ipilimumab and nivolumab) on advanced non-epithelial ovarian cancers (NEOCs) in patients who have no other effective treatments available.
- In a clinical trial involving 17 patients, the therapy showed a 25% overall response rate in those with granulosa cell tumors, with some patients experiencing significant progression-free survival and overall survival benefits.
- However, the therapy had serious side effects, leading to treatment discontinuation in 18% of participants and no positive responses noted in carcinosarcoma cases.
Article Synopsis
- Suspension syndrome occurs when a person experiences cardio-circulatory collapse while hanging vertically, with ongoing debate about its causes.
- A scoping review by ICAR MedCom analyzed various studies to clarify the syndrome's pathophysiology and provide updated recommendations for its management.
- The findings suggest that suspension syndrome can lead to serious complications, including bradycardia and loss of consciousness, and emphasize the importance of prevention strategies and quick medical intervention in case of an emergency.
Background: Chemo-radiation is a well-established alternative to radical cystectomy in patients with muscle-invasive bladder cancer. Many patients due to age or medical comorbidity are unfit for either radical cystectomy, or standard cisplatin- or 5-fluorouracil-based chemoradiation, and do not receive appropriate treatment with curative intent. We treated patients with a less aggressive protocol employing seven weekly doses of paclitaxel and daily irradiation.
View Article and Find Full Text PDFIntroduction: The International Commission for Mountain Emergency Medicine (ICAR MedCom) developed updated recommendations for the management of avalanche victims.
Methods: ICAR MedCom created Population Intervention Comparator Outcome (PICO) questions and conducted a scoping review of the literature. We evaluated and graded the evidence using the American College of Chest Physicians system.